Dandelion Polysaccharides Ameliorate High-Fat-Diet-Induced Atherosclerosis in Mice through Antioxidant and Anti-Inflammatory Capabilities

Dandelion (Taraxacum officinale), a member of the Asteraceae (Compositae) family, is well known as traditional medical plant. polysaccharides, natural active ingredient extracted from dandelion, possess immune regulation, anti-inflammatory, antioxidant, and anti-aggregation properties. These properties suggest that dandelion polysaccharides might alleviate atherosclerosis. Using an ApoE−/− atherosclerotic mice model fed high-fat diet, we investigated impact potential mechanism on We observed significantly reduced levels triglyceride, total cholesterol, low-density lipoprotein-cholesterol in serum, while elevated high-density level. Concomitantly, area lesions necrotic core aortic sinus, increased collagen content. Mechanistic studies showed were effective reducing serum malondialdehyde elevating enzymatic activities superoxide dismutase glutathione peroxidase. Furthermore, expression chemotactic factor Mcp-1 pro-inflammatory cytokines (Tnf-α, Il-1β, Il-6) lesions. Overall, these results indicated may take important part attenuation atherosclerosis via its antioxidant anti-inflammatory